what does it mean to be kell positive

The test looks for … (Sadly, two losses in a row are common; docs don’t usually ‘worry’ until the third.) It appears I’m quite an anomaly, but I guess we knew that. I’m 35 weeks and have slight anemia as I did with my 1st baby. I know this because the pregnancy and baby were completely normal.i am expecting again and dad has not been tested yet.i was just wondering if there is a chance he could be kell postive after 7 healthy pregnancy and babies .all same dad? They did a titer all they told me was that it is an 8 ?…. Best wishes — Kyra. That means the partner of the diabetic man is more likely to have miscarriages because the sperm that fertilizes the egg may be “broken”. This means that you have antibody to Kell which means that if you did not have as blood transfusion that you were exposed to the Kell antigen when delivering your baby. No trouble during that pregnancy. If he is actually heterozygous (Kk) then yes, you were VERY lucky but not beyond rational expectations. I say that it’s more look like a woman with a blood type of “-” marrying a man with blood type “+”. So of you are Kk, then are you positive or negative? Once you are sensitized you can be too low to titer but should you get pregnant again w a K+ baby chances are your body will will have the same reaction. Also, if a baby is cellano-negative (which it might very well be and indeed probably is) then the body won’t attack the fetus; your antigens won’t “see” anything there to attack. Le rhésusest une particularité génétique : on est toujours du même rhésus qu'il soit positif ou négatif. It is actually very rare to develop these antibodies, even if your husband is kell positive and you are kell negative. In addition, you have a fundamental misunderstanding of McLeod sydrome. 2. I was born 3 weeks early, with jaundice much more severe than my sister or brother had. As I am spending a fortune on fertility treatments, and have had every other test in the book done, I would like to find out if the Kell and other antigens/antibodies could have caused the problem. What does it mean to be “sex positive?” This is one of those terms that different people define in different ways; however, at the core of most definitions is the idea that we must recognize that human sexuality—in its diverse and myriad forms of expression—is natural and healthy. My question is will my son have any Kell at all? What do you see as an expert? the baby has kell positive plus anti kell antibodies? Our mothers are both O+ Kell-. After my first born I had a transfusion that obviously contained the Kell antibodies. Not only Rh-, m-n- and KK? It says K-k+ is the most common Kell group in Europeans. Path to improved health. Or would the kell positive woman still need medical advice/help to conceive and carry to term? I have been wondering if the tables could be turned, could the father produce a K positive baby and mom be k negative. I think it would have to be a deficient immune response by your own body and I have no knowledge about that topic. Unless one of the offspring reproduces with a Kell positive partner (which is a less than 10% chance) no grandchildren will be Kell positive, and so on forevermore. And yet, 38 years later, here I am. the trips r 3 hrs up and 3 hrs back each visit. I am currently in the same situation and am totally baffled! Your body won’t attack a Kell+ baby because it is the SAME and it won’t attack a Kell- baby because there is no antigen there to set it off. Remember, YOU are here and you were obviously a Kell+ fetus at one point. Could I get severe anemic? Baby 3 I had to have a c sec and transfusion. I believe, if I understand the timeline, this is your first baby since you contracted the anti-kell antibodies. How did I not get weeded out of the genetic pool generations ago. 2nd pregnancy I had kell antibodies but since Dad is Neg and my pregnancy went on as normal. The BAD news is that if either of your sons have your blood type then their partners might (and it is a big if considering genetics) have issues IF the partner is a normal K- and IF the second fetus is K+. i found out about 2 months ago that i have the kell anti-body. One antigen showed up in a our third pregnancy and now there are three with this fourth pregnancy. But how did Henry get that Kell positive gene? I am sure your physician will take excellent care of you. Really wish they would screen blood for this when someone donates, it is scary for women to have to go thtough this. I just have a biology degree and study doctors. The Kell blood type system is highly polymorphic, meaning that there are many different alleles (alternative forms of a gene) - about 25! In basic terms from what I read, Kell is where the mother's body attacks that fetus because it recognizes the fetus as a foreign invader. And even if he DID have the Kell gene, there is lots they could do for his future reproductive partner, and many people with K+ men get lucky and get 3 Kell negative babies in a row. Detection of viral RNA does not necessarily mean that a person is infectious and able to transmit the virus to another person. thanks. Even if he does happen to be kell positive (very unlikely) then your baby will still be safe since you don’t have anti-kell antibodies. He is 100% the father as well. Any university would probably have such an expert that you could email. if the mother has anti kell anti bodies and the father has a kell positive (heterozygous) Kk. When antibodies are found on the mother’s red blood cells, the mother is referred to as being “Kell positive.” What Does It Mean to Be Kell Positive or Kell Negative? I hope you and your new baby are very healthy! The good news is that, as far as I can tell, your husband’s lack of a Kell positive gene means your body will not reject the fetus you are carrying. Any advice? Your little girl must be Kell+ and #9 must be Kell+ or your body would not be making antigens. If you get a non-Kell sperm then (if all else is normal) you will have a healthy pregnancy and a hearty little baby at the end of it without any big medical interventions. If all four children are girls, and they each are Kk, then Kell positive blood is very likely to show up in the grandchildren. This is in addition to the ABO blood groups that most people know about. Continue to take steps to protect yourself. Une personne est rhésus négatif si ses globules rouges ne portent pas à leur surface de mol… Moreover, random chance can make a dominate gene go bye-bye even when the dominate gene doesn’t cause the death of many offspring who inherit it. What are some viable reasons these antigens could be in her system? They’ll need to get tested, because your daughters will have no reproductive issues, if your son has the Kk then his reproductive partner’s Ob/Gyn will need to know to keep a close eye on her pregnancies. There is unlikely to be any insurmountable obstacles preventing your from having children … it may just take longer and be harder. There’s really not much information out there for this problem that many young moms face today. Multiple pregnancy losses are agonizing to go through, but more common than people realize. It has NOTHING to do if they are KK, or kk, or Kk. Things I know — it is rare, but anti-K antibodies can show up in a first pregnancy, so you aren’t alone. Now I have anti-kell showing up on my blood test. Is Kell only spread by the men? But you interpret those results to mean I am Kk so he has a chance? My second child, my son, had mild haemolytic disease of the newborn. and where that came from? I too became anti-kell from a blood transfusion. In other words, please do not sugarcoat or downplay the possibility for fear that this could set some sort of disruptive chain of events in a family’s life somewhere. Also I think maybe some people are getting g mixed up on this sight. I wonder if there is anyway that we can change this? I was wondering if the woman above ever figured out any answers as to how she contracted the antibody? Is that correct? An RhD positive baby will only have rhesus disease if their RhD negative mother has been sensitised to RhD positive blood. Okay, the GOOD news is that as a K+ woman your pregnancies will never be effected. Your first born son will need to be tested to know for sure. I sincerely appreciate your consideration. I am currently 18 weeks pregnant. If the antibody was not being expressed the next time the patient has an antibody screen that screen will be positive. Advice… Other articles have told me that the antigen is very common, while the antibody is not so much. If it is a first pregnancy, then the mother’s body will not attack the fetus even if it is Kell positive. Oldest is a boy 2nd is a girl the rest all boys .my anit bodies only showed up for my last baby who is now 2 no issues during pregnancy I was watched close. What happens if I don’t pass it on to the fetus and I’m positive but fetus is negative? Also, there are HUNDREDS of antigens a partner could pass to baby that mother doesn’t have– many in the Rh system, Kell system, Kidd system, Duffy, Dombrock, etc. If they are Kell negative, you’ll know the test for your husband was off a bit and that he is Kk, not KK. If you test positive, know what protective steps to take to prevent others from getting sick. Odds are good your body will always make enough red blood cells for you. It is an antigen on the red blood cell. I phoned the midwife to enquire and was told she made a clerical error, no antibodies in my blood. Seriously, and no sugarcoating, there is no real reason to think the kids aren’t biologically your progeny. If you plan to have more children, you might want to get your husband to go for a blood test to see if he has Kell+ blood. Sperm meets Ms. Did they double check? The only way to know if she has the anti-Kell antigens is to go to an Ob/Gyn and get the blood tests done to detect them. It could avoid heartbreak in the future. That episode stressed me out a lot I had to ask my parents about it without telling them Im pregnant… but im glad it was just a mistake. If you are antigen typed and are Kell positive this means you cannot make a antibodies to Kell. I did indeed *almost* die in the womb, and the Obstetrician said I probably wouldn’t live very long after birth at the rate things were going. Everyone would have two of these genes, so people with Kell positive blood are either “KK” or “Kk”, and people with Kell negative blood are “kk”. After losing two pregnancies, I was blessed with three healthy babies in a row. Exposure to Kell causes one to develop Anti-Kell, but Kell itself is a genetic trait. I’m currently 33 weeks pregnant. Could you respond by email too because I don’t think I could find this feed again if I tried . But now I am pregnant again and I have the anti kell antibody. Once she’s exposed, she develops anti-Kell antibodies, which can attack and destroy Kell-positive red blood cells. I sincerely hope all goes well! When my husbands blood came back, he is kell negative. 5 yearsz ago i had my 1st son and had to have an emergency c-section which caused me to have blood transfusions to save my life. Did her Ob/Gyn not test for Kell antibodies in her blood after the third miscarriage? However, it is the third most common blood type which is present in about 1 out of 12 individuals. Let’s say mom has brown eyes of BB and dad has blue. First, I think s/he is correct about your blood work being normal. You cannot have both. Bc my antibodies no longer titered my OB did NOT want to do an amnio to determine if my baby was K+. I wish I could be more help. What this means is you can place your iPhone on a wireless charging pad and the iPhone would charge wirelessly without having to connect a charger. My husbands blood work came back negative for the kell antigen. I’d be worried about the antibodies that you contracted not the antigen Kell. Take brown eyes and blue eyes, for example. Once you get a bb in the mix those little b genes are lurking in every gonad. PLEASE let me know what the results were if you get a son tested for Kell!! Once a person has expressed recessive genes, there are NO dominate genes to pass on to their kids. Your first pregnancy will not be affected by kell antigens (but could still be one of the 1/3 lost pregnancies; there are lots of things that can go wrong with a normal pregnancy). Kell is the most agressive antibody. I wrote you earlier, but my blog didn’t post it. The ABO gene found on chromosome 9 determines the ABO blood group system. This blood type is present in about 33% in Caucasians, 24% in African American, 29% in Hispanic, and 27% in Asian. I have had it for two pregnancies ( pregnant with my 5th now, but this issue did not arise until my last pregnancy). Thank Goodness all is ok, but now I don’t think I can donate Blood anymore which is sad as I am However, if your husband doesn’t have the Kell gene to give your baby, then your body should have no reason to attack her. O genes … I have a 3 year old daughter and my blood test was negative for anti kell antibodies when I had her. If the boys are Kell-negative, then they have no worries. Every one of their kids will have brown eyes because of the B, but they will all be carrying the blue b as well. I have never had a blood transfusion and was A+ all my life until after baby #1. Rare, in that you are less than 10% of the population? Something that drew me to this article is that my last name is Cary, as in Mary Boleyn Cary, mistress of Henry VIII. They all have irregular antibodies. I’m the first child of my parents (Kk, my father is KK, my mother is kk). The B Positive blood type is extremely valuable where matching supply for the demand has been a constant challenge. However, if you have a Kell+ son and his future partner is Kell- then they need to give her a doctor a heads up when/if she gets pregnant. The first pregnancy typically carries to term and produces a healthy infant, even if the infant is Kell positive and the mother is Kell negative. I have just found out that I had K antibodies in my blood tests in my second pregnancy. I see there’s some confusion about Kell vs. Anti-Kell. (Well, it used to be like that before modern medical treatments that will keep a Kell positive fetus alive inside a Kell negative mother. Thank you so much. You are still A+ blood type (as am I). If I am Kell +, & My husband is Kell -, babies + or – is currently unknown . I am not a medical doctor, only a medical anthropologist, and I can but speculate that your first born had a K+ blood type and now you have antigens that will attack any K+ tissue, including another Kell+ fetus. My baby girl is due in 3 months, even with a c section I can bleed out. Okay, remember that I am NOT an MD and thus your OB/Gyn outranks me by a factor of 20. Antibodies are found in serum/plasma. I am really sorry, and I hope medical intervention keeps both you and the baby healthy and the outcome is a joyous one. This is in addition to the ABO blood groups that most people know about. Une personne estrhésus positif (+)si ses globules rouges portent, à leur surface, une certaine molécule, appelée molécule rhésus. However, your sibling’s birth is unusual because there should have been enough alloimmunization to effect the pregnancy. Her pregnancy with SS2 was just fine but she did have a C-sections and was "exposed" to this antigen or whatever it is. I am sure the doctors are taking all reasonable precautions, tho. I went through my last pregnancy (4th child) and had MCA scans, and my baby girl was born healthy and not anemic. Your body recognized the foreign part of the blood (Kell) and built up antibodies to get rid of it… In the same way your body builds up antibodies to get rid of an infection. First, congratulations on your healthy family! Since there is only a 50/50 of a first born getting the K gene, maybe only 2 out of the 16 hypothetical grandchildren will be Kell positive. Kell may become more common now. Because the New Year’s Boy survived for a few weeks and Mary lived to adulthood. I wish we had the $ for the full bloodwork for my husband, as we are only finding put of he is positive or negative for the antigens. Any babies before or after that Kell positive pregnancy that did NOT inherent the Kell antigen were NOT affected. However, if all four children are boys then the Kell gene is much less likely to turn up in the grandchildren, because every pregnancy after the FIRST one will only survive if it is Kell negative (kk). I would recommend retesting Dad because a false negative is the most likely explanation. This test is frequently performed on newborn babies. Now, what would happen if a Kell positive person reproduced with a Kell negative person? We are waiting for the results of my husbands bloodwork, I have Kell and Kidd antibodies. 2. Since I have B negative blood, and my partner O positive I did the direct and indirect Coombs tests after both of my losses to check for RH issues, and they were negative. Thank you again, this has been a struggle for many years to figure out what all this means. Okay, the odds that your bloodwork gave a false negative is MUCH higher than the odds of any kids being not yours. I sincerely hope all of your subsequent pregnancies bring you such joyful results as well! And what is an antigen—anything capable of causing a reaction. Thanks a lot, I have 7 boys and 1 girl baby number 9 gender not yet known what does being kell positive mean to them and their future offspring please. Random chance works like that. A little bit about the Kell positive blood type, on A little bit about the Kell positive blood type, Click to email this to a friend (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Tumblr (Opens in new window), Click to share on Pinterest (Opens in new window), Click to share on Pocket (Opens in new window), Click to share on Telegram (Opens in new window), Click to share on WhatsApp (Opens in new window), Click to share on Skype (Opens in new window), http://www.sciencealert.com/artificial-blood-could-be-used-in-trial-transfusions-by-2016. Do you mean you have Kell antibody. I think if your antibodies are that high, then your body has been sensitized. Hi Kyra thanks for replying. If she doesn’t have the anti-Kell antigens, then the pregnancy will have no more risks than the average and you can still go to a midwife. In my family of origin I am the eldest of five surviving siblings, four girls and 1 boy, with one additional sibling dying at or before birth between each of us for a total of nine children between my parents. If you do get a Kell positive fetus then there ARE things the doctor can do to save the pregnancy. I hope this pregnancy and any future pregnancies go smoothly and without complications! I am still confused by this, after I had my first born (daughter) I went to donate blood and was sent a letter that stated there was not a need for my blood type, when I became pregnant with my son I had to go through a amiosenthesis and had a very straining pregnancy. Did they test your husband for both K1 (Kell) and K2 (Cellano) genes, or was it just a blood test? However, not all of the ethnic groups share the same proportions of A positive blood types. Hopefully I am going for an ultersound soon to Check blood flow in brain.as I am 17 weeks now. My husband has been tested and he is Negative for K (Kell), positive for k (cellano). For one thing, people who are homozygous (KK) for Kell are rare. He had some jaundice, and was in an incubator for awhile, but it wasn’t too serious. help You can get the boys tested now and then they can warn their wife/partner if and when pregnancy is a possibility. The presence of Kell antibodies can be detected by maternal blood testing. The funny thing about a Kell positive blood type is that the Kell antigen is passed on by a dominate gene, but even though it is dominate it is rare; less than 10% of the people in the UK have it. Just wanted to add my blood type is A+ , my mum told me I had jaundice and mild anemia when I was born. This pregnancy would be the first fetus after a kell positive pregnancy to have the Kell antigen, so it would be your SECOND Kell positive baby. I worry, a little, for my half-brother and my sister’s son, that they will have trouble if they want 2 kids, or if they have a partner who has had a prior Kell+ transfusion to react to. You are fine except that if you need a blood transfusion in the future you will have to have blood that is antigen negative for Kell. Your daughter will not be troubled by Kell+ because her body will not attack the fetus either with or without Kell. I knew this, and understood it rationally, but when I had two miscarriages in a row I was still devastated because the heart tends to ignore the brain. I feel like a blood group freak. I’d love to find it. I had to get a blood transfusion after. I had my first two babies via midwife, so I understand the desire for a low-intervention pregnancy and delivery, but if your wife has the anti-Kell antigens then the pregnancy is officially high risk and will need to go the full biomedical intervention route. Either the Kell did not ‘turn on’ and make itself known, or your mom’s body doesn’t have a profound alloimmunizational response. I did have a transfusion. Well I am 13 weeks pregnant now, and I just was informed by my doctor that I have the anti-kell antigan. That’s right. Because there is a more than 90% chance that one of their parents was Kell negative, and thus had only k genes to bring to the party. I wonder if my blood type is actually a connector, although according to the heredity patterns, could the Kk have survived through a father line? Synopsis. My wife’s titers are elevated as she has a number of antigens or antibodies (not sure which is which) in her blood- I believe they were called Kell, E and another… There are three of them. The Kell antigen system (or the Kell-Cellano system) was named after the family of the antibody producer Mrs. Kellacher. Does that mean I got this from my parents? And that’s awesome you have 3 precious babies! O-Neg….I appreciate your response have a wonderful day. The Kell antigen system (also known as Kell–Cellano system) is a human blood group system, that is, group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. I have O Positive k-Cellano negative blood. Kell is not a blood type. Probably Anti-K based on what you described. Glad it all worked out!!! Secondly, when Kell positive people with the typical Kk genotype reproduce with one of the Kell negative (kk) majority, each child has only a 50/50 chance of being Kell positive. HOWEVER, just being from England (which the name Cary is) means your ancestors had a 9% chance of carrying the gene. Do you remember the Punnett Square from middle school biology classes? I would encourage you if you are ever hospitalized to be sure that you tell your nurses and doctors that you have an antibody. It means that a blood test, called a Coombs test, or Direct Antibody Test (DAT), was done on your baby and was positive. My kids were all blood typed as O+. Thanks so much for getting back to me.my titer level is 1.8 which is pretty high. KK people are VERY rare. Inheritance Patterns. We are waiting for my son’s results right now. If your next baby has no Kell antigen, then it will be fine. That being said, a Kell+ woman will not have any problems with pregnancy because of her blood type. Or if I get pregnant again will it come back? This post will provide a tad more information as to what it is exactly and how it is transmitted. But my husband did not get tested.and if he is postive why would all my other children be fine and why did it just show up 2 years ago .I had the blood transfusion in 2003 and I have had 3 kids in that time all boys.and I had 3 already before that.could my husband still test postive?I am 15 weeks now with my 8 and my level is high at 1.8? Would I be safe assuming that my first daughter would be kk and my son kk and my youngest child Kk ? Report as Inappropriate. I’m assuming if I’m positive and fetus is positive there is no problem. I have the same situation as you, during the 6-th pregnancy it appeared I have Kell antigens. Thus it is critical this is passed off to a dr who specializes in this condition. Thanks for writing back and for explaining how the Kell blood type will effect me. Again, I am sorry for your many losses and I hope you have reproductive success in the future. And the most common for Europeans and Africans was the K-k+. You should now take the advice from a MFM vs an OB. you should be fine. But in some breast cancers, the HER2 gene produces too many proteins. I became Kell antigen positive after receiving a blood transfusion while giving birth. Yes, Rh and Kell antibodies are a concern because tend to be relatively immunogenic and cause more severe hemolytic disease of the newborn because they are expressed by a fetus so early and women lose babies. Gladys Tan. If you live where you have access to an obstetrician, then there is a lot they can do to make any subsequent kell-effected pregnancies go well. Ok so I am pregnant with baby 4. My hubby tested positive for kell antigen and is homogenous for kell so all our kids are kell positive , can you please explain how he is homogenous for kell antigen , my pregnancy is now 34 weeks and my tillers have remained stable at 1:28 but today have doubled , baby shows no signs of anaemia via mca scan and no signs of hydrous but they want to deliver in 2 weeks , what does the rise in antibodies mean? This is my first pregnancy after a year of trying (about 7 weeks now) and I am very worried…Do you have any advice for me please?

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